NAG Factor

23,80 $

22 w magazynie

Kategorie: , SKU: 2230001 Tag:

Opis

NAG Factor to inaczej N-ACETYL GLUCOSAMINE czyli okolo 1000x krotnie skutecznijesza forma glukozaminy od wersji HCL , w zaleznosci od zrodel ktore sie czyta.
W praktycznym zastosowaniu to czuc zdecydowanie.
Power X Sport jako jedyna marka w Polsce oferuje 100% czysta i orginalna wersje N-ACETYL GLUCOSAMINE w przecieiwienstwie do tych ktorym sie wydaje ze maja orginal a w rzeczywistosci oferuja zwykla wersje HCL
Produkt jest w Veganskich kapsulkach co ulatwia i uskutecznia dzialanie substancji.
Ponadto ta wersja glukozaminy wytrzwarz nowe mitochondria w komorkach miesniowych , tazke nie tylko leczy stawy ale poprawia prace miesni !

Poznizej, dla niedowiarokow referencje z badan na ludziach.

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References :
1. Dieppe P, Chard J, Lohmnader S, Smith C. Osteoarthritis. Clin Evid. 2002;7:1091–90. [Google Scholar]
2. Reginster JY. The prevalence and burden of arthritis. Rheumatology (Oxford) 2002;41:3–6. [PubMed] [Google Scholar]
3. Goldberg SH, Von Feldt JM, Lonner JH. Pharmacologic therapy for osteoarthritis. Am J Orthop. 2002;31:673–80. [PubMed] [Google Scholar]
4. Rubin BR, Talent JM, Kongtawelert P, Pertusi RM, Forman MD, Gracy RW. Oral polymeric N-acetyl-D-glucosamine and osteoarthritis. J Am Osteopath Assoc. 2001;101:339–44. [PubMed] [Google Scholar]
5. Christgau S, Henrotin Y, Tanko LB, Rovati LC, Collette J, Bruyere O, et al. Osteoarthritic patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulphate. Clin Exp Rheumatol. 2004;22:36–42. [PubMed] [Google Scholar]
6. Hughes R, Carr A. A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee. Rheumatology (Oxford) 2002;41:279–84. [PubMed] [Google Scholar]
7. Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med. 2002;162:2113–23. [PubMed] [Google Scholar]
8. Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001;357:251–6. [PubMed] [Google Scholar]
9. Shikhman AR, Amiel D, D’Lima D, Hwang SB, Hu C, Xu A, et al. Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis. Ann Rheum Dis. 2005;64:89–94. [PMC free article] [PubMed] [Google Scholar]
10. Uldry M, Ibberson M, Hosokawa M, Thorens B. GLUT2 is a high affinity glucosamine transporter. FEBS Lett. 2002;524:199–203. [PubMed] [Google Scholar]
11. Richardson S, Neama G, Phillips T, Bell S, Carter SD, Moley KH, et al. Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation. Osteoarthritis Cartilage. 2003;11:92–101. [PubMed] [Google Scholar]
12. Shikhman AR, Brinson DC, Valbracht J, Lotz MK. Cytokine regulation of facilitated glucose transport in human articular chondrocytes. J Immunol. 2001;167:7001–8. [PubMed] [Google Scholar]
13. Shikhman AR, Brinson DC, Lotz MK. Distinct pathways regulate facilitated glucose transport in human articular chondrocytes during anabolic and catabolic responses. Am J Physiol Endocrinol Metab. 2004;286:E980–5. [PubMed] [Google Scholar]
14. Otte P. Basic cell metabolism of articular cartilage: manometric studies. Z Rheumatol. 1991;50:304–12. [PubMed] [Google Scholar]
15. Lee RB, Urban JP. Evidence for a negative Pasteur effect in articular cartilage. Biochem J. 1997;321:95–102. [PMC free article] [PubMed] [Google Scholar]
16. Kim JJ, Conrad HE. Kinetics of mucopolysaccharide and glycoprotein synthesis by chick embryo chondrocytes: effect of D-glucose concentration in the culture medium. J Biol Chem. 1976;251:6210–7. [PubMed] [Google Scholar]
17. Sweeney C, Mackintosh D, Mason RM. UDP-sugar metabolism in Swarm rat chondrosarcoma chondrocytes. Biochem J. 1993;290:563–70. [PMC free article] [PubMed] [Google Scholar]
18. Mankin HJ, Dorfman H, Lippielo L, Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am. 1971;53:523–37. [PubMed] [Google Scholar]
19. Hresko RC, Heimberg H, Chi MM, Mueckler M. Glucosamine-induced insulin resistance in 3T3-L1 adipocytes is caused by depletion of intracellular ATP. J Biol Chem. 1998;273:20658–68. [PubMed] [Google Scholar]
20. Liu J, Shikhman AR, Lotz MK, Wong CH. Hesoxaminidase inhibitors as new drug candidates for the therapy of osteoarthritis. Chem Biol. 2001;8:701–11. [PubMed] [Google Scholar]
21. Mason RM, Sweeney C. The relationship between proteoglycan synthesis in Swarm chondrocytes and pathways of cellular energy and UDP-sugar metabolism. Carbohydr Res. 1994;255:255–70. [PubMed] [Google Scholar]
22. Nelson BA, Robinson KA, Buse MG. High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes. Diabetes. 2000;49:981–91. [PubMed] [Google Scholar]
23. Bosch RR, Bazuine M, Wake MM, Span PN, Olthaar AJ, Schurmann A, et al. Inhibition of protein kinase C beta II increases glucose uptake in 3T3-L1 adipocytes through elevated expression of glucose transporter 1 at the plasma membrane. Mol Endocrinol. 2003;17:1230–9. [PubMed] [Google Scholar]
24. Von der Crone S, Deppe C, Barthel A, Sasson S, Joost HG, Schurmann A. Glucose deprivation induces Akt-dependent synthesis and incorporation of GLUT1, but not of GLUT4, into the plasma membrane of 3T3-L1 adipocytes. Eur J Cell Biol. 2000;79:943–9. [PubMed] [Google Scholar]
25. Samih N, Hovsepian S, Notel F, Prorok M, Zattara-Cannoni H, Mathieu S, et al. The impact of N- and O-glycosylation on the functions of Glut-1 transporter in human thyroid anaplastic cells. Biochim Biophys Acta. 2003;1621:92–101. [PubMed] [Google Scholar]
26. Somwar R, Koterski S, Sweeney G, Sciotti R, Djuric S, Berg C, et al. A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation. J Biol Chem. 2002;277:50386–95. [PubMed] [Google Scholar]
27. Cuenda A, Alessi DR. Use of kinase inhibitors to dissect signaling pathways. Methods Mol Biol. 2000;99:161–75. [PubMed] [Google Scholar]
28. Konrad RJ, Zhang F, Hale JE, Knierman MD, Becker GW, Kudlow JE. Alloxan is an inhibitor of the enzyme O-linked N-acetylglucosamine transferase. Biochem Biophys Res Commun. 2002;293:207–12. [PubMed] [Google Scholar]
29. Kim JJ, Conrad HE. Kinetics of mucopolysaccharide and glycoprotein synthesis by chick embryo chondrocytes. Effect of D-glucose concentration in the culture medium. J Biol Chem. 1976;251:6210–7. [PubMed] [Google Scholar]
30. McDonald JA, Camenisch TD. Hyaluronan: genetic insights into the complex biology of a simple polysaccharide. Glycoconj J. 2002;19:331–9. [PubMed] [Google Scholar]
31. Tan CH, Peterson NA, Raghupathy E. Characteristics of D-glucosamine uptake by rat brain synaptosomes. J Neurochem. 1977;29:261–5. [PubMed] [Google Scholar]
32. Baron AD, Zhu JS, Zhu JH, Weldon H, Maianu L, Garvey WT. Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity. J Clin Invest. 1995;96:2792–801. [PMC free article] [PubMed] [Google Scholar]
33. Rajpurohit R, Koch CJ, Tao Z, Teixeira CM, Shapiro IM. Adaptation of chondrocytes to low oxygen tension: relationship between hypoxia and cellular metabolism. J Cell Physiol. 1996;168:424–32. [PubMed] [Google Scholar]
34. Stockwell RA. Metabolism of Cartilage. In: Hall BK, editor. Cartilage: Structure, Function and Biochemistry. Vol. 1. Academic Press; 1983. pp. 253–280. [Google Scholar]
35. Qu CJ, Karjalainen HM, Helminen HJ, Lammi MJ. The lack of effect of glucosamine sulphate on aggrecan mRNA expression and (35)S-sulphate incorporation in bovine primary chondrocytes. Biochim Biophys Acta. 1762:453–9. [PubMed] [Google Scholar]
36. Qu CJ, Jauhiainen M, Auriola S, Helminen HJ, Lammi MJ. Effects of glucosamine sulfate on intracellular UDP-hexosamine and UDP-glucuronic acid levels in bovine primary chondrocytes. Osteoarthritis Cartilage. 2007;15:773–9. [PubMed] [Google Scholar]
37. Kleine TO, Stephan R. Biosynthesis of chondroitin sulfate side chains and hyaluronate. Time-course studies with cartilage slices of calf ribs under different conditions. Biochim Biophys Acta. 1976;451:444–56. [PubMed] [Google Scholar]
38. Sweeney C, Mackintosh D, Mason RM. UDP-sugar metabolism in Swarm rat chondrosarcoma chondrocytes. Biochem J. 1993;290:563–70. [PMC free article] [PubMed] [Google Scholar]
39. Noyszewski EA, Wroblewski K, Dodge GR, Kudchodkar S, Beers J, Sarma AV, et al. Preferential incorporation of glucosamine into the galactosamine moieties of chondroitin sulfates in articular cartilage explants. Arthritis Rheum. 2001;44:1089–95. [PubMed] [Google Scholar]
40. Bassleer C, Rovati L, Franchimont P. Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro. Osteoarthritis Cartilage. 1998;6:427–34. [PubMed] [Google Scholar]
41. Mroz PJ, Silbert JE. Effects of [3H]glucosamine concentration on [3H]chondroitin sulphate formation by cultured chondrocytes. Biochem J. 2003;376:511–5. [PMC free article] [PubMed] [Google Scholar]
42. De Mattei M, Pellati A, Pasello M, de Terlizzi F, Massari L, Gemmati D, et al. High doses of glucosamine-HCl have detrimental effects on bovine articular cartilage explants cultured in vitro. Osteoarthritis Cartilage. 2002;10:816–25. [PubMed] [Google Scholar]
43. Parri ME, Virkamaki A, Landaker EJ, Kahn CR, Yki-Jarvinen H. Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. Diabetes. 1999;48:1562–71. [PubMed] [Google Scholar]
44. Filippis A, Clark S, Proietto J. Increased flux through the hexosamine biosynthesis pathway inhibits glucose transport acutely by activation of protein kinase C. Biochem J. 1997;324:981–5. [PMC free article] [PubMed] [Google Scholar]
45. Biggee BA, Blinn CM, McAlindon TE, Nuite M, Silbert JE. Low levels of human serum glucosamine after ingestion of glucosamine sulphate relative to capability for peripheral effectiveness. Ann Rheum Dis. 2006;65:222–6. [PMC free article] [PubMed] [Google Scholar]

Informacje dodatkowe

Waga 0,1 kg
Dystrybutor

Power X Sport

Opinie

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